Causes of Gangrene: Main Reasons, Risk Factors & Early Warning Signs

The causes of gangrene are mainly related to poor blood circulation, severe bacterial infections, or traumatic injuries that damage body tissues. Conditions such as diabetes, peripheral artery disease, atherosclerosis, smoking, and untreated wounds significantly increase the risk of developing gangrene. Infections caused by bacteria can rapidly spread in tissues with low oxygen supply, leading to tissue death. Injuries from burns, frostbite, surgery, or accidents can also trigger gangrene if proper medical care is not provided. Understanding the causes of gangrene helps in early diagnosis, timely treatment, and prevention of serious complications such as amputation or life-threatening infections.